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6 and 2 times the human dose based on surface area of lopid to female rats from gestation day 15 through weaning caused dose-related decreases in birth weight and suppressions of pup growth during lactation.
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although there are no in vivo data with which to predict the magnitude or clinical significance of this potential interaction, caution should be used when selegiline is coadministered with clopidogrel.
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be sure to mention angiotensin-converting enzyme ace inhibitors such as benazepril lotensin , captopril capoten , enalapril vasotec , fosinopril monopril , lisinopril prinivil, zestril , moexipril univasc , perindopril, aceon , quinapril accupril , ramipril altace , and trandolapril mavik ; anticoagulants blood thinners such as warfarin coumadin ; aspirin and other nonsteroidal anti-inflammatory medications nsaids such as ibuprofen advil, motrin and naproxen aleve, naprosyn ; beta blockers such as atenolol tenormin , labetalol normodyne , metoprolol lopressor, toprol xl , nadolol corgard , and propranolol inderal ; calcium channel blockers such as amlodipine norvasc , diltiazem cardizem, dilacor, tiazac, others , felodipine plendil , isradipine dynacirc , nicardipine cardene , nifedipine adalat, procardia , nimodipine nimotop , nisoldipine sular , and verapamil calan, isoptin, verelan ; chloramphenicol; clarithromycin biaxin ; cyclosporine neoral, sandimmune ; disopyramide norpace ; diuretics water pills ; fluconazole diflucan , fluoxetine prozac, sarafem ; gemfibrozil lopid , hormone replacement therapy and hormonal contraceptives birth control pills, patches, rings, implants, and injections ; insulin or other medications to treat high blood sugar or diabetes; isoniazid inh ; mao inhibitors such as isocarboxazid marplan , phenelzine nardil , selegiline eldepryl, emsam, zelapar , and tranylcypromine parnate ; medications for asthma and colds; medications for mental illness and nausea; miconazole monistat ; niacin; oral steroids such as dexamethasone decadron, dexone , methylprednisolone medrol , and prednisone deltasone ; phenytoin dilantin ; probenecid benemid ; quinolone and fluoroquinolone antibiotics such as cinoxacin cinobac , ciprofloxacin cipro , enoxacin penetrex , gatifloxacin tequin , levofloxacin levaquin , lomefloxacin maxaquin , moxifloxacin avelox , nalidixic acid neggram , norfloxacin noroxin , ofloxacin floxin , sparfloxacin zagam , trovafloxacin and alatrofloxacin combination trovan ; rifampin; salicylate pain relievers such as choline magnesium trisalicylate, choline salicylate arthropan , diflunisal dolobid , magnesium salicylate doan s, others , and salsalate argesic, disalcid, salgesic ; sulfa antibiotics such as co-trimoxazole bactrim, septra ; sulfasalazine azulfidine ; and thyroid medications.
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in addition, patients treated with effient also had significantly fewer stent thromboses stent-related blood clots compared to those treated with clopidogrel.
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After a single, oral dose of 75 mg, clopidogrel has a half-life of approximately 6 hours.
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