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Trazodone is a good drug but in my opinion it should not be taken daily for more then a few weeks.
Lack of m4 formation by cyp3a4 in incubations of trazodone can be explained by lower binding affinity of the formed m -cpp compared with trazodone, whereas the reason that cyp2d6 did not form m4 is that the n -dealkylation of trazodone to form m -cpp was primarily mediated by cyp3a4.
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In endogenous depression trazodone is efficacious in doses approximately twice that of imipramine.
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i have recently stopped taking trazodone after 2 years of use.